Area Proteomica


Signore M et al.
UCN-01 enhances cytotoxicity of irinotecan in colorectal cancer stem-like cells by impairing DNA damage response.
Oncotarget. 2016 Jul 12;7(28):44113-44128. doi: 10.18632/oncotarget.9859.

De Angelis ML et al.
Cancer Stem Cell-Based Models of Colorectal Cancer Reveal Molecular Determinants of Therapy Resistance.
Stem Cells Transl Med. 2016 Apr;5(4):511-23. doi: 10.5966/sctm.2015-0214.

Marziali G, Signore M et al.
Metabolic/Proteomic Signature Defines Two Glioblastoma Subtypes With Different Clinical Outcome.
Sci Rep. 2016 Feb 9;6:21557. doi: 10.1038/srep21557.

Trono P et al.
hMENA(11a) contributes to HER3-mediated resistance to PI3K inhibitors in HER2-overexpressing breast cancer cells.
Oncogene. 2016 Feb 18;35(7):887-96. doi: 10.1038/onc.2015.143. Epub 2015 May 11.

Signore M et al.
Combined PDK1 and CHK1 inhibition is required to kill glioblastoma stem-like cells in vitro and in vivo.
Cell Death Dis. 2014 May 8;5:e1223. doi: 10.1038/cddis.2014.188.

Forte S et al.
Gene expression analysis of PTEN positive glioblastoma stem cells identifies DUB3 and Wee1 modulation in a cell differentiation model.
PLoS One. 2013 Dec 12;8(12):e81432. doi: 10.1371/journal.pone.0081432.

Sette G et al.
EGFR inhibition abrogates leiomyosarcoma cell chemoresistance through inactivation of survival pathways and impairment of CSC potential.
PLoS One. 2012;7(10):e46891. doi: 10.1371/journal.pone.0046891.

Francescangeli F et al.
Proliferation state and polo-like kinase1 dependence of tumorigenic colon cancer cells.
Stem Cells. 2012 Sep;30(9):1819-30. doi: 10.1002/stem.1163.

Signore M, Reeder KA.
Antibody validation by Western blotting.
Methods Mol Biol. 2012;823:139-55. doi: 10.1007/978-1-60327-216-2_10.

Napoletani D et al.
Homologous control of protein signaling networks.
J Theor Biol. 2011 Jun 21;279(1):29-43. doi: 10.1016/j.jtbi.2011.03.020.

VanMeter A, Signore M, Pierobon M, Espina V, Liotta LA, Petricoin EF 3rd.
Reverse-phase protein microarrays: application to biomarker discovery and translational medicine.
Expert Rev Mol Diagn. 2007 Sep;7(5):625-33. Review.

Spreafico F et al.
Proteomics analysis of cerebrospinal fluid from children with Central Nervous System tumors identifies candidate proteins relating to tumor metastatic spread.
Oncotarget (submitted, second round of revision)

Manic G & Signore M et al.
CHK1-targeted therapy to deplete DNA replication-stressed, p53-deficient hyperdiploid colorectal cancer stem cells.
Gut (submitted, second round of revision)

Haas TL et al.
Identification of Integrin Alpha 7 as Functional Marker and Potential Therapeutic Target in Glioblastoma Multiforme.
Cell Stem Cell (submitted, second round of revision)