https://corefacilities.iss.it/dw/ 2026-04-29T16:19:09+02:00 https://corefacilities.iss.it/dw/ https://corefacilities.iss.it/dw/lib/tpl/bootstrap3gscf/images/favicon.ico text/html 2020-10-29T13:39:05+02:00 https://corefacilities.iss.it/dw/doku.php?id=en:aree:epr:attivita:alimenti EPR Area Food science Page under construction text/html 2020-10-29T13:43:01+02:00 https://corefacilities.iss.it/dw/doku.php?id=en:aree:epr:attivita:analisi_segnale EPR Area Signal analysis The EPR spectrum of a paramagnetic center (radical, metals, crystalline defects, ...) contains information on the structure and molecular dynamics of the center and its surroundings. This information can be extracted from the spectrum shape by using specifically developed software based mainly on the simulations of the spin Hamiltonian interactions. text/html 2020-10-30T18:56:13+02:00 https://corefacilities.iss.it/dw/doku.php?id=en:aree:epr:attivita:macromolecole EPR Area Macromolecules (spin labeling) EPR spectroscopy allows to study the structure, function and dynamics of macromolecules and cellular components, the intramolecular distances and the specific role of some amino acid residues through site-specific mutagenesis in absence and presence of perturbator agents. text/html 2020-10-29T13:40:23+02:00 https://corefacilities.iss.it/dw/doku.php?id=en:aree:epr:attivita:materiali EPR Area Material science Page under construction text/html 2020-10-30T18:56:46+02:00 https://corefacilities.iss.it/dw/doku.php?id=en:aree:epr:attivita:metalli_proteine EPR Area Metals and metalloproteins Transition metals (iron, copper, manganese, cobalt, ...) are paramagnetic because of the incomplete electron orbital. In some oxidation states, transition metals may however lose paramagnetic properties. EPR spectroscopy can then detect the presence of transition metals for example in the contamination of materials (eg from chromium, iron or manganese) or in macromolecules (metalloproteins). text/html 2020-10-30T15:54:01+02:00 https://corefacilities.iss.it/dw/doku.php?id=en:aree:epr:attivita:radiazioni_ionizzanti EPR Area Ionizing radiation Ionizing and non-ionizing radiations induce stable radicals in solid matrices. EPR allows a qualitative and quantitative evaluation of such radiation-induced radicals which act as indicators of exposure. A quantitative assessment of the exposure can be obtained by using a calibration curve. text/html 2020-10-30T18:56:25+02:00 https://corefacilities.iss.it/dw/doku.php?id=en:aree:epr:attivita:ros EPR Area Free radicals and oxidative stress Free radicals participate to tissue physiological metabolic processes by reversibly altering the activity/function of specific target molecules. In presence of chemical, physical and biological agents, levels of free radicals can be significantly and permanently increased. This condition, called text/html 2025-08-18T13:22:33+02:00 https://corefacilities.iss.it/dw/doku.php?id=en:aree:epr:attivita:sidebar Start Access regulation to the Service Service requests Brochure Reserved section ---------- Areas Cytometry EPR SpectrometersOther instrumental resourcesArea activitiesFree radicals and oxidative stressIonizing radiationMetals e metalloproteinsMacromolecules (spin labelling)Food scienceMaterials scienceSignal analysisDevelopment of instrumentation Links & tutorialsPublicationsService requestWho we are NMR & MRI Microscopy Proteomics Next Generation Sequencing Sc… text/html 2020-10-29T13:10:26+02:00 https://corefacilities.iss.it/dw/doku.php?id=en:aree:epr:attivita:start EPR Area Area activities [Free radicals and oxidative stress] [Metals and metalloproteins] [Signal analysis] [Macromolecules (spin labelling] [Alanine dosimetry] [Development of instrumentation] [Food science] [Materials science] text/html 2020-10-29T13:45:05+02:00 https://corefacilities.iss.it/dw/doku.php?id=en:aree:epr:attivita:sviluppo_strumentazione EPR Area Development of instrumentation Our laboratory has experience in the design and manufacture of accessories of the EPR spectrometer useful for specific experimental needs. In this we collaborate with the Faculty of Engineering of the University of Rome