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en:aree:epr:attivita:metalli_proteine [2018/08/07 15:50] Gianluca Frustagli English translation. |
en:aree:epr:attivita:metalli_proteine [2020/10/30 18:56] (current) Paola Fattibene |
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| - | > FIXME **To be revised.**\\ //(remove this paragraph once finished)// | ||
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| **EPR Area** | **EPR Area** | ||
| ====== Metals and metalloproteins ====== | ====== Metals and metalloproteins ====== | ||
| - | + | Transition metals (iron, copper, manganese, cobalt, ...) are paramagnetic because of the incomplete electron orbital. In some oxidation states, transition metals may however lose paramagnetic properties. | |
| - | {{:aree:epr:attivita:heme-b.png?150 |Heme B}} Transition metals (iron, copper, manganese, cobalt, ...) are paramagnetic because of the incomplete electron orbital. In some oxidation states, transition metals may however lose paramagnetic properties. | + | |
| EPR spectroscopy can then detect the presence of transition metals for example in the contamination of materials (eg from chromium, iron or manganese) or in macromolecules (metalloproteins). | EPR spectroscopy can then detect the presence of transition metals for example in the contamination of materials (eg from chromium, iron or manganese) or in macromolecules (metalloproteins). | ||
| In this case the metals are paramagnetic only in some functional states of the macromolecules, their monitoring allows to obtain information about the numerous cellular processes in which these macromolecules (cytochromes, proteins containing iron-sulfur clusters, hemoglobin, ceruloplasmin, transferrin) are involved (eg, bioenergetics, signaling). | In this case the metals are paramagnetic only in some functional states of the macromolecules, their monitoring allows to obtain information about the numerous cellular processes in which these macromolecules (cytochromes, proteins containing iron-sulfur clusters, hemoglobin, ceruloplasmin, transferrin) are involved (eg, bioenergetics, signaling). | ||
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| + | \\ | ||
| > Contact: [[donatella.pietraforte@iss.it|Donatella Pietraforte]] | > Contact: [[donatella.pietraforte@iss.it|Donatella Pietraforte]] | ||
| > ☎ **+39 06 4990 2907** | > ☎ **+39 06 4990 2907** | ||
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| + | /* > FIXME **To be revised.**\\ //(remove this paragraph once finished)// */ | ||
