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en:aree:epr:attivita:macromolecole [2018/02/16 17:02]
Gianluca Frustagli Links fixed
en:aree:epr:attivita:macromolecole [2020/10/29 13:36]
Gianluca Frustagli Some changes in text.
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-> FIXME **This page is not fully translated, yet.**\\ //(remove this paragraph once the translation is finished)//+**EPR Area**
  
-**Area EPR**+====== Macromolecules (spin labeling) ======
  
-====== Macromolecole (spin labelling) ======+{{:​aree:​epr:​attivita:​macromolecole.png?​300 |Macromolecules}} EPR spectroscopy allows to study the structure, function and dynamics of macromolecules and cellular components, the intramolecular distances and the specific role of some amino acid residues through site-specific mutagenesis in absence and presence of perturbator agents.
  
-{{:​aree:​epr:​attivita:​macromolecole.png?​300 |Macromolecole}} La spettroscopia EPR consente di studiare la strutturala funzione e la dinamica di macromolecole e componenti cellularile distanze intramolecolari e il ruolo specifico di alcuni residui aminoacidici tramite mutagenesi sito-specifica in assenza e presenza di agenti perturbatori.+Since the mobility of spin labels depends strictly on the macromolecular structureany alteration of this structureinduced by the microenvironment,​ has effects on the EPR signals generated by the spin labels.
  
-A questo scoposi utilizza la tecnica dello **spin labeling**, ​che consiste nella marcatura di specifici residui amminoacidici delle proteine con opportune molecole paramagnetiche ​(spin labels) ​tramite legami covalenti.+For this purposethe **spin labeling** ​technique is usedwhich consists in marking specific amino acid residues of proteins with appropriate paramagnetic molecules ​(spin labels) ​through covalent bonds.
  
-Poiché la mobilità degli spin labels dipende strettamente dalla struttura macromolecolare,​ ogni alterazione di quest'​ultima indotta dal microambiente ha effetti sui segnali EPR generati dagli spin labels.+\\
  
-Contatto: [[donatella.pietraforte@iss.it|Donatella Pietraforte]]+Contact: [[donatella.pietraforte@iss.it|Donatella Pietraforte]]
 > ☎ **+39 06 4990 2907** > ☎ **+39 06 4990 2907**
 +
 +/* > FIXME **To be revised.**\\ //(remove this paragraph once finished)// */